Isothermal Microcalorimetry as a Quality by Design Tool to Determine Optimal Blending Sequences

Standards in Isothermal Microcalorimetry

The main calorimetric principles used in isothermal microcalorimetry are briefly discussed. Different chemical calibration and test reactions are discussed, with a focus on reactions suitable for ambient conditions: reactions initiated by mixing of liquids (including titration microcalorimetry), dissolution of solid compounds and of slightly soluble gases, a photochemical process, and thermal p...

Isothermal microcalorimetry in applied biology

Techniques of isothermal microcalorimetry have been much improved during the past two decades. In addition to their use in fundamental research, applications of practical importance have been established in some areas. However, no significant use of isothermal microcalorimetry has yet been seen in practical applications of biology, despite many methodological studies reported from that area. Th...

Isothermal Microcalorimetry, a New Tool to Monitor Drug Action against Trypanosoma brucei and Plasmodium falciparum

Isothermal microcalorimetry is an established tool to measure heat flow of physical, chemical or biological processes. The metabolism of viable cells produces heat, and if sufficient cells are present, their heat production can be assessed by this method. In this study, we investigated the heat flow of two medically important protozoans, Trypanosoma brucei rhodesiense and Plasmodium falciparum....

Microcalorimetry as a tool for structural biology MICROCALORIMETRY MOLECULAR STRUCTURE LABEL-FREE ANALYSIS BINDING AFFINITY

Quantitative Characterization of sorption through isothermal microcalorimetry

inTroDuCTion When a problem is encountered in the production or storage of solid dosage forms, invariably the problem is somehow connected to the sorption of water. In the presence of water, the physical properties of solids may be altered causing changes in flow properties, free volume, and compressibility; or there may be an accelerated interconversion between polymorphic forms seriously affe...